Optimization of the Preparation Technology of Ferulic Acid/K/β-CD/Metal Organic Framework Inclusion
10.6039/j.issn.1001-0408.2016.07.22
- VernacularTitle:阿魏酸/钾/β-环糊精金属有机骨架包合物的制备工艺优化
- Author:
Xiaoning YANG
;
Xiumei ZHANG
;
Lianhe WU
;
Jingquan SHA
;
Xiya YANG
;
Lu FANG
- Publication Type:Journal Article
- Keywords:
Ferulic acid;
Cyclodextrin metal organic framework;
Inclusion complex;
Orthogonal design
- From:
China Pharmacy
2016;27(7):936-938
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare Ferulic acid/K/β-CD/metal organic framework (FA/K/β-CD/MOF) inclusion,and to opti-mize its preparation technology. METHODS:K/β-CD/MOF was synthesized by solvothermal method as inclusion material. Using FA as main component,FA/K/β-CD/MOF was prepared by grinding method. The preparation technology was optimized by orthogo-nal test using mole ratio of main component-inclusion material,grinding time,dropping time and inclusion temperature as factors, inclusion rate as index. Prepared FA/K/β-CD/MOF was indentified by IR spectrum and DSC,and inclusion rate and dissolution rate were determined. RESULTS:Optimized preparation technology was as follows as mole ratio of main main component to inclusion material 3∶1,dropping time 60 min,inclusion temperature 40 ℃,inclusion time 60 min. Prepared FA/K/β-CD-MOF had already formed a new kind of phase,and its average inclusion rate was(18.0±1.6)%(RSD=0.9%,n=6);its solubility was 15 times as much as FA(9.582 mg/ml vs. 0.647 mg/ml). CONCLUSIONS:FA/K/β-CD/MOF is prepared successfully;and the preparation tech-nology is reasonable and feasible.
