Preparation Technology Screening of Activated Carbon N-acetylcysteine Microcapsule
10.6039/j.issn.1001-0408.2016.07.28
- VernacularTitle:乙酰半胱氨酸活性炭微囊的制备工艺筛选
- Author:
Hongying FANG
;
Rangxiao ZHUANG
;
Xuwang PAN
;
Jingjing SUN
;
Jianjun XI
;
Fugen WANG
;
Tingting SHI
;
Shourong LIU
- Publication Type:Journal Article
- Keywords:
Activated carbon;
N-acetylcysteine;
Microcapsule;
Preparation technology;
Emulsion cross-linked method;
Orthog-onal test
- From:
China Pharmacy
2016;27(7):955-958
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare Activated carbon N-acetylcysteine microcapsule (ACNAC),and to optimize preparation technology. METHODS:ACNAC was prepared by emulsion cross-linked method using biodegradable material gelatin as capsule wall material. Using comprehensive evaluation index of drug-loading amount,entrapment rate and particle size distribution percent-age(the percentage of 80-140 μm particle)as index,drug-loading ratio,amount of gelatin,mixing speed and the amount of emul-sifier as factors,single factor test and orthogonal test were used to optimize formulation technology. The technology was validated and distribution of particle size of ACNAC was determined. RESULTS:The optimal formulation technology was as follows as drug-loading ratio 1∶1,gelatin 15%,emulsifier 2.0%,mixing speed 1 000 r/min. Average drug-loading amount of 6 batches of ACNAC was 15.9%(RSD=1.21%),average encapsulation efficiency was 78.1%(RSD=1.11%)and average particle size distri-bution percentage was 81.9%. CONCLUSIONS:ACNAC is prepared successfully,and formulation technology is reasonable and feasible.
