Effects of Ossotide Tablet Combined with Xianling Gubao Capsule on the Postoperative Recovery of Trans-traumatic-verterbrae Screw-setting Combined with Bone Grafting in the Treatment of Osteoporotic Thoracolumbar Vertebral Fractures
10.6039/j.issn.1001-0408.2016.06.09
- VernacularTitle:骨肽片联合仙灵骨葆胶囊对经伤椎置钉结合植骨治疗骨质疏松性胸腰椎骨折术后恢复效果的影响
- Author:
Junbo DONG
- Publication Type:Journal Article
- Keywords:
Ossotide tablet;
Xianling gubao capsule;
Osteoporotic thoracolumbar fracture;
Recovery effect
- From:
China Pharmacy
2016;(6):746-748
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of Ossotide tabletcombined with Xianling gubao capsule on the postoperative recovery effect oftrans-traumatic-verterbrae screw-setting combined with bone grafting in the treatment of osteoporotic thoracolum-bar vertebral fractures. METHODS:122 patients with osteoporotic thoracolumbar vertebral fractures who were treated with trans-traumatic-verterbrae screw-setting combined with bone grafting were randomly divided into control group and observation group.The two groups were treated by trans-traumatic-verterbrae screw-setting with bone grafting.Based on this,the control group was treated with 0.3-0.6 g Ossotide tablet,three times a day,taken orally after meals;observation group was additionally treated with 1.5 g Xianling gubao capsule,twice a day,taken orally after meals. Both of the two groups took medicine on the day of oper-ation. A course induded 4 weeks,and it lasted 4 courses. The indexes were observed after 3 and 6 months treatment. The changes of pain score,bone mineral density(BMD)levels,bone gla protein(BGP),bone alkali phsphatase(BALP),procollagen I ntermi-nal peptide (PINP) and other bone metabolism biochemical indexes in 2 groups before and after treatment were observed.Mean-while,the clinical efficacy,rates of thoracolumbar vertebral refractures and incidence of adverse reactions in the 2 groups were re-corded.RESULTS:After treatment,the total effective rate in observation group was significantly higher than control group,pain scores in 2 groups were significantly lower than before,and general decreased by time,observation group was lower than control group;BMD,BGP,BALP and PINP levels in 2 groups were significantly higher than before,and general increased by time,ob-servation group was higher than control group;after 6 months,BMD,BALP and PINP levels in control group were significantly higher than before,the differences were statistically significant(P<0.05);there were no significant differences in the incidence of adverse reactions,rates of thoracolumbar vertebral refractures between 2 groups(P>0.05). CONCLUSIONS:Ossotide tablet com-bined with Xianling gubao capsule can significantly improve the bone metabolism biochemical indexes of patients,promote bone mineral density and fracture healing,with good safety in short-term medication.
