Analysis of Vancomycin-induced Neutropenia Adverse Reactions/Adverse Events in Children
10.6039/j.issn.1001-0408.2016.06.14
- VernacularTitle:万古霉素致儿童中性粒细胞减少不良反应/不良事件分析
- Author:
Huanhuan JI
;
Jian LUO
;
Lin SONG
;
Bo ZHOU
;
Xiaoying TIAN
;
Yuntao JIA
- Publication Type:Journal Article
- Keywords:
Vancomycin;
Neutropenia;
Correlation;
Children;
ADR/ADE
- From:
China Pharmacy
2016;(6):760-762
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide reference for vancomycin-induced neutropenia adverse reactions/adverse events in clinical diagnosis. METHODS:With a case of children with neutropenia treated by long-course and large-dose vancomycin,PubMed and CNKI were retrieved to collect related literature and the literature was analyzed. RESULTS:Neutropenia may be associated with vancomycin,based on causality criterion of adverse reaction in China. CONCLUSIONS:Vancomycin-induced neutropenia in chil-dren is most likely associated with prolonged exposure induced by infusion,vancomycin dosage should be reduced or stopped,and routine blood and plasma concentration should be closely monitored.
