Clinical Observation of Fluorometholone Combined with Ganciclovir in the Treatment of Herpes Simplex Keratitis
10.6039/j.issn.1001-0408.2016.06.18
- VernacularTitle:氟米龙联合更昔洛韦治疗单疱病毒性角膜炎的临床观察
- Author:
Xuan LIU
- Publication Type:Journal Article
- Keywords:
Fluorometholone;
Ganciclovir;
Herpes simplex keratitis;
Efficacy;
Safety
- From:
China Pharmacy
2016;(6):771-773
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of fluorometholone combined with ganciclovir in the treatment of herpes simplex keratitis. METHODS:72 patients with herpes simplex keratitis were randomly divided into control group and study group. Control group was treated with 1 drop of 0.15% Ganciclovir ophthalmic gel,4 times every day;shallow-type patients were treated with 0.15% Ganciclovir ophthalmic gel for 2-5 d,then 0.2 g Fluorometholone tablet was orally given when corneal epitheli-al repaired to positive fluorescein staining,3 times a day + 25 mg Indomethacin tablet,orally,3 times a day;deep-type patients were additionally treated with 1 drop of Compound tropicamide eye drop,once every morning and night. Shallow-type patients in study group were treated with 0.15% Ganciclovir ophthalmic gel for 2-5 d,then 1 drop of 0.025% Flumetholon eye drop was giv-en when corneal epithelial repaired to positive fluorescein staining,4 times every day+Indomethacin tablet(the same dose with con-trol group)+Indomethacin tablet(the same dose with control group);deep-type patients were additionally treated Compound tropi-camide eye drop(the same dose with control group). The treatment course for both groups was 7 d. Clinical efficacy,average treat-ment time,recurrence rate and incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in study group was significantly higher than control group,average treatment time was significantly shorter than control group,recur-rence rate was significantly lower than control group,the differences were statistically significant(P<0.05). There was no signifi-cant difference in the total effective rate for shallow-type patients between 2 groups(P>0.05);the total effective rate for deep-type patients in study group was significantly higher than control group,the difference was statistically significant(P<0.05). There were no obvious adverse reactions during treatment,and liver and kidney function,blood and urine routine showed no abnormality. CON-CLUSIONS:Fluorometholone combined with ganciclovir has significant efficacy in the treatment of herpes simplex keratitis,it can significantly shorten treatment course and reduce recurrence rate,with good safety,especially for deep-type patients.
