Effects of Recombinant Human Interferon α1b Combined with Ribavirin on Thyroid Function in Chronic Hepatitis C Patients
10.6039/j.issn.1001-0408.2016.05.29
- VernacularTitle:干扰素α1b联合利巴韦林对慢性丙型肝炎患者甲状腺功能的影响
- Author:
Yongsheng YANG
;
Guiqin HUANG
- Publication Type:Journal Article
- Keywords:
Recombinant human interferonα1b;
Chronic hepatitis C;
Thyroid disease
- From:
China Pharmacy
2016;27(5):666-668
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of recombinant human interferon (IFN)α1b on thyroid function of patients with chronic hepatitis C(CHC). METHODS:Retrospective collection 90 CHC patients,according to whether to merge with hyper-thyroidism into hypothyroidism group,hypothyroidism group and CHC group,30 cases in each group. 3 groups were given IFN-α1b 40μg,qod,combined with ribavirin 0.1 g,tid,for antiviral therapy. Before and after therapy,RVR,EVR,ETVR and SVR were observed in 3 groups,and the levels of T3,T4,FT3,FT4 and TSH were observed in hypothyroidism group,hypothyroidism group before and after antiviral therapy. RESULTS:After treatment,RVR,EVR,ETVR and SVR levels of 3 groups increased sig-nificantly,with statistical significance,compared with before treatment(P<0.05).After treatment,there was no statistical signifi-cance in RVR,EVR,ETVR and SVR among 3 groups,there was no statistical significance(P>0.05);there was no statistical sig-nificance in the levels of T3,T4,FT3,FT4 and TSH before and after treatment(P>0.05). CONCLUSIONS:IFN-α1b combined with ribavirin can obtain good antiviral effect and not worsen existing thyroid disease in the treatment of CHC complicated with thy-roid disease.
