Correlation of Antibacterials Amount with Drug Resistance of Escherichia coli in Our Hospital from 2012 to 2014
10.6039/j.issn.1001-0408.2016.05.10
- VernacularTitle:我院2012-2014年抗菌药物用量与大肠埃希菌耐药率的相关性分析
- Author:
Jing ZHAO
;
Yanli MA
;
Meiying NING
;
Zhong ZHANG
;
Jizhang YANG
- Publication Type:Journal Article
- Keywords:
Escherichia coli;
Drug resistance;
Antibacterials;
Correlation
- From:
China Pharmacy
2016;27(5):608-612
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the correlation between antibacterials amount and drug resistance of Echerichia coli,and to provide reference for clinical use of antibacterials. METHODS:Retrospective review was used to calculate DDDs of antibacterials and resistance rate of Escherichia coli to 11 kinds of antibacterials each quarter. The correlation analysis was carried out using the SPSS 13.0 statistical software. RESULTS:The resistance rates of E. coli to piperacillin/tazobactam,cefoperazone/sulbactam and le-vofloxacin were with upward trends,and the others showed downward trends. The resistance rates of E. coli to meropenem and imi-penem/cilastatin appeared in 2014,increasing from 0 to 8.8% and 9.4%,respectively. DDDs of them were significantly correlated to drug resistance of E. coli,showing positive correlation(r=0.915,0.793,P<0.01). DDDs of piperacillin/tazobactam was signif-icantly correlated to resistance rate of E. coli(r=0.807,P<0.01),while that of ceftazidime was negatively correlated to resistance rate of E. coli(r=-0.672,P<0.05). There was no statistical significance in resistance rate of E. coli to other 7 kinds of antibacte-rials. CONCLUSIONS:There are some correlations between the DDDs and resistance rates. We should strengthen the monitoring of bacterial resistance and the management of rational application of antibacterials.
