Efficacy Observation of Urinary Kallidinogenase in the Treatment of Acute Cerebral Watershed Infarct
10.6039/j.issn.1001-0408.2016.05.23
- VernacularTitle:尤瑞克林治疗急性分水岭脑梗死患者的疗效观察
- Author:
Bin WANG
;
Yang LIU
;
Xiaoyuan LI
;
Jing WANG
;
Fengyun ZHANG
;
Fulian MA
;
Shuqin LIU
- Publication Type:Journal Article
- Keywords:
Urinary kallidinogenase;
Cerebral watershed infarct;
Neurologic impairment score;
Serum complement
- From:
China Pharmacy
2016;27(5):650-652
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe clinical efficacy of urinary kallidinogenase in the treatment of acute cerebral watershed in-farct (WSI). METHODS:128 patients with WSI were randomly divided into control group and treatment group,each of the 64 cases. Control group was given Shuxuening 15 ml added into 0.9% Sodium chloride 250 ml,ivgtt,qd;treatment group received urinary kallidinogenase 0.15 PNA added into 0.9% Sodium chloride 100 ml,ivgtt,qd. Both groups were treated for consecutive 14 days. Neurologic impairment score(NIHSS)and clinical efficacy were observed in 2 groups before treatment and 3,7 and 14 days after treatment. The blood specimens were collected after 7 and 14 days treatment,to determine serum levels of TCC. RESULTS:After treatment,NIHSS and total effective rate of treatment group were significantly higher than those of control group,with statis-tical significance(P<0.01). There was no statistical significance in TCC between 2 groups before treatment(P>0.05);7 days af-ter treatment,TCC level of 2 groups increased significantly,to 14 days,and a declive;the treatment group was higher than the control group,with statistical significance (P<0.05). CONCLUSIONS:Urinary kallidinogenase can improve clinical efficacy of WSI significantly,and promote neurologic impairment symptom and TCC levels.
