The Effects of Green Tea Extracts (Polyphenon E, EGCG) in Human Papilloma Virus Positive Cervical Lesion.
- Author:
Hyun Sun KO
1
;
Seung Won HUH
;
Su Mi BAE
;
Seung Ae SON
;
Jae Eun CHUNG
;
Dong Kun JIN
;
In Su LEE
;
Jeong Im SIN
;
Joon Mo LEE
;
Sung Eun NAMKOONG
;
Woong Shick AHN
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Korea.
- Publication Type:Original Article
- Keywords:
Green tea Extracts;
EGCG;
Polyphenon E;
Cervical Cancer;
HPV
- MeSH:
Humans*;
Papilloma*;
Tea*;
Uterine Cervical Neoplasms;
Uterine Cervicitis
- From:Korean Journal of Obstetrics and Gynecology
2003;46(2):410-422
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: We tried to confirm the effects of green tea extracts (polyphenon E, EGCG) in patients with human papilloma virus (HPV) positive cervical lesion. METHODS: We divided 51 HPV positive cervical lesion patients (chronic cervicitis, mild dysplasia, moderate dysplasia and severe dysplasia) into 4 group and 37 patient as placebo control. We applied poly E ointment two times per week (27 patients), poly E ointment plus poly E capsule (8 patients), poly E capsule (6 patients), EGCG capsule (10 patients) 200 mg each for 8 to 12 weeks. RESULTS: Among 27 patients with poly E ointment group, 20 patients responded (74%), such as chronic cervicitis (12/18), mild dysplasia (4/5), moderate dysplasia (2/2) and severe dysplasia (1/2). Among 8 patients with poly E ointment and poly E capsule group, 6 patients responded (75%), 6 patients poly E capsule group responded 3 patients (50%). 10 EGCG capsule patients group responded 6 patients (60%). Overall responsive rate is 69% (35/51) in case of green tea extracted treated group and 10% (4/39) in placebo controlled group (P<0.05). CONCLUSION: The effects of green tea extract in HPV positive cervical lesion were statistically significant (P<0.05). This result suggests that green tea extract has highly potential of new treatment agent for HPV infected cervical lesion.
