Norovirus P particle and its application
10.3760/cma.j.issn.0254-5101.2016.09.015
- VernacularTitle:诺如病毒P粒子及其应用研究进展
- Author:
Jialiang DU
;
Tai GUO
- Publication Type:Journal Article
- Keywords:
Norovirus;
P particle;
Virus-like particle;
Vaccine
- From:
Chinese Journal of Microbiology and Immunology
2016;36(9):716-720
- CountryChina
- Language:Chinese
-
Abstract:
The challenges posed by norovirus infections to global health are increasing accompa-nied by the rapid rate of the genetic and antigenic evolution of circulating noroviruses. Due to lack of in vitro culture cells and small animal models, norovirus vaccine cannot be prepared by using traditional techniques. With the in-depth understanding and study of norovirus, the subunit vaccines against norovirus infection based on P particles have been developed and presented the characteristics of easily expressed, low cost, high immunogenicity, stable structure and so on. In addition, norovirus P particle has been used as a subvi-ral nanoparticle for vaccine development against other viruses and for antibody production against chronic dis-ease ( Alzheimer′s disease) , which benefits from the accommodation of foreign antigens in the three loops of P particle. In this review, we describe the progresses in the field of P particle related vaccines for providing suggestions about the research and development of multivalent vaccines in China.
