Correlation analysis of human papilloma virus variant intratumoral high-risk subtypes and cervical intraepithelial distribution
10.3760/cma.j.issn.1008-6706.2016.22.009
- VernacularTitle:高危型人乳头瘤状病毒基因亚型分布与宫颈上皮内瘤变的相关性分析
- Author:
Xiaoxia JIA
;
Guijing QIU
- Publication Type:Journal Article
- Keywords:
HPV subtypes;
Cervical intraepithelial neoplasia;
Correlation analysis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(22):3396-3399
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the county high-risk women human papilloma virus (HPV)type distribution and subtypes of cervical intraepithelial neoplasia relevance,designed to provide a clinical risk assessment theoretical support.Methods 520 female patients with first visit high-risk HPV infection were selected.All subjects were HPV subtypes was measured and cervical intraepithelial neoplasia pathology,accounting analysis and correlation analysis and different subtypes of HPV accounting for patients with cervical lesions.Results 520 cases of HPV subtypes result patients showed that HPV infection subtypes,HPV16,HPV18,HPV31 and HPV58 infection higher proportion (44.8%,19.2%,11.5% and 16.7%),other types of infection was relatively low.520 cases of HPV infection in patients with CIN Ⅰ and CIN Ⅱ-Ⅲ and cervical squamous cell carcinoma was more,more than 15.0% of the total, a relatively small proportion of other types of cancer patients.In paragraph CIN Ⅱ-Ⅲ,HPV16 infection subtypes higher proportion of more than 60.0%,while the other was closer in cervical intraepithelial neoplasia,there was no difference between the written press and hold;in squamous cell carcinoma,accounting for HPV31 subtype only inferior HPV16(24.3%),which was significantly higher than the proportion of cervical adenocarcinoma (9.5%)(χ2 =3.821,P =0.049).Conclusion HPV infection in patients with high-risk subtypes higher risk of cervical lesions, require special attention,neoplasia different risks in different subtypes of patients infected cervical epithelium,clinical research is worth attention.
