The study of clinical effect and mechanism on Jianpi-Huayu decoction preventing against ;recurrence of colonic adenoma after endoscopic mucosal resection
10.3760/cma.j.issn.1673-4246.2016.10.004
- VernacularTitle:健脾化瘀汤对内镜下大肠腺瘤切除术后复发的影响
- Author:
Xiaoqin ZHANG
;
Yamin HE
- Publication Type:Journal Article
- Keywords:
Jianpi-Huayu decoction;
Colonic;
Adenoma;
Transanal endoscopic surgery;
Recurrence;
Cyclooxygenase 2;
Ki67
- From:
International Journal of Traditional Chinese Medicine
2016;38(10):877-879
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To observe the effect of Jianpi-Huayu decoction for preventing the patients from the recurrence of colonic adenoma after endoscopic mucosal resection. Methods A total of 60 patients with colonic adenoma who received endoscopic mucosal resection were divided randomly into the experimental group (taking Jianpi-Huayu decoction) and the controlled group (taking nothing as treatment), 30 patients in each group. Both groups were treated for 1 year. After 1 year, colonscopy was taken, and the number and size of colonic adenoma were recorded. The expression of COX-2, Ki67 in the colonic mucosa were detected the immunohistochemistry, and the negative rate of COX-2, Ki67 were also detected. Results After the treatment, the number (0.20 ± 0.48 vs. 1.67 ± 1.54, t=4.980) and size (0.23 ± 0.57 vs. 2.73 ± 2.80, t=4.788) of colonic adenoma in the experimental group were statistically lower than those in the ontrolled group (P<0.01);the expression of COX-2 (1.96 ± 1.27 vs. 3.64 ± 1.95, t=3.673) and Ki67 (2.04 ± 1.46 vs. 4.50 ± 1.73, t=5.558) in the the experimental group were statistically lower than those in the ontrolled group (P<0.01). The number of the paitents whose COX-2, Ki67 negative rates in the experimental group were 21 and 22, and the control group were 12(P=0.004) and 14 (P<0.001), which showed the significant difference between two groups. Conclusions The Jianpi-Huayu decoction could reduce recurrence of colonic adenoma after endoscopic mucosal resection, the mechanism was decreasing the expression of COX-2, Ki67 in colonic mucosa.
