Study of the feasibility on medical gas suction feeding device for replicating model of respiratory failure in dogs
10.11958/20160029
- VernacularTitle:医用气源汲送装置复制呼吸衰竭犬模型的可行性研究
- Author:
Herong WANG
;
Qi WU
;
Xin SUN
;
Shasha FU
- Publication Type:Journal Article
- Keywords:
medical gas suction feeding device;
respiratory failure;
models,animal;
dogs;
feasibility
- From:
Tianjin Medical Journal
2016;44(10):1229-1232
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feasibility and stability of medical gas suction feeding device for copying the model of respiratory failure in dogs. Methods The self-designed medical gas suction feeding device was used to establish the model of respiratory failure in dogs. After regulating the proportion of oxygen (O2), carbon dioxide (CO2) and nitrogen (N2), the fraction of inspiration O2 (FiO2) was decreased, while the forced inspiratory carbon dioxide (FiCO2) was increased. At the same time, the breathing out pathway was open to make the arterial oxygen partial pressure p (O2) and arterial blood carbon dioxide partial pressure p (CO2) reached and stabilized in a stable condition. The arterial blood samples between default state and 1 hour, 2 hour after modeling were collected to detect the blood gas index. Results One hour after the establishment of model, the p (O2) was≤60 mmHg (1 mmHg=0.133 kPa), and p (CO2) was≥50 mmHg (1 mmHg=0.133 kPa), which suggested that the dog model of respiratory failure was established successfully. Compared with the basic state, data of pH, oxygen content, oxygen saturation (SaO2) and residual alkali (BE) were decreased at 1 hour and 2 hour after modeling (P < 0.05). The p (O2), oxygen content, SaO2 were decreased in 2 hour after modeling compared with those of 1h after modeling (P<0.05). There were no significant differences in pH, p (CO2), TCO2, HCO3-and BE between 1 hour and 2 hour after modeling (P > 0.05). Conclusion Under the regulation of the medical gas suction feeding device, the respiratory failure state of large experimental animals is successfully established.
