The risk assessment of antiplatelet medications in angiogram -negative subarachnoid hemorrhage
10.3760/cma.j.issn.1008-6706.2016.22.014
- VernacularTitle:抗血小板聚集药在血管造影阴性蛛网膜下腔出血应用中的风险探讨
- Author:
Taipeng ZHANG
;
Hai XIAO
;
Chong WEI
;
Xingyue QIN
;
Qiudi LIU
- Publication Type:Journal Article
- Keywords:
Platelet aggregation inhibitors;
Negative reactions;
Cerebral angiography;
Subarachnoid hemorrhage
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(22):3416-3418
- CountryChina
- Language:Chinese
-
Abstract:
Objective The influence of antiplatelet medications on prognosis after non -aneurysmal subarachnoid hemorrhage(SAH)is unknown.This study aimed to evaluate the risk of antiplatelet mdications in devel-oping SAH.Methods 420 patients who underwent catheter cerebral angiography after presenting with nontraumatic SAH were included.Outcomes were assessed by using the modified Rankin scale.Results A total of 420 patients underwent catheter angiography for evaluation of SAH.Of these,63 cases (15%)were angiogram -negative.The fraction of patients presenting with angiogram -negative SAH as well as the frequency of antiplatelet use among these patients significantly increased during the study period.Antiplatelet use was more commonly associated with angiogram-negative SAH(18 /63,28.6%)than with angiogram -positive SAH(39 /357,11%;P =0.001).At 14 days after presentation,poor outcome was significantly more frequent among patients who took antiplatelet agents (20 /63, 31.7%)than among those who did not(12 /63,20%;P =0.017).Conclusion Antiplatelet medication use is asso-ciated with poor early,but not late,outcomes after angiogram -negative SAH.More studies are needed to confirm this association.
