The relationship of Neuroligin1, synapses and cognitive dysfunction
10.16571/j.cnki.1008-8199.2016.10.020
- VernacularTitle:神经连接蛋白1与神经突触及认知功能障碍的关系
- Author:
Dan LUO
;
Hui TANG
;
Lili QIU
;
Jianjun YANG
- Publication Type:Journal Article
- Keywords:
Synapses;
Neuroligin1;
Neurexin1;
Cognitive dysfunction
- From:
Journal of Medical Postgraduates
2016;29(10):1097-1100
- CountryChina
- Language:Chinese
-
Abstract:
All information processing and transmission in the brain involves synapses, the synaptic cell adhesion molecules play an important role in the formation, maturation and maintenance of synapses. Neuroligin1 ( NL1) is excitatory postsynaptic trans?membrane cell adhesion molecules. The interaction between NL1 and other molecules, such as Neurexin1 ( NRXN1) , involves in the formation, plasticity and function of synapses. NL1 knockout or overexpression displayed impairment in learning and memory, thus sug?gesting that NL1 participates in the pathophysiology of neuropsychiatric disease with cognitive dysfunction. Therefore, study of NL1 will open up new avenues to understand pathogenesis of cognitive dysfunction, and may provide a novel insight into prevention and treatment of cognitive dysfunction?associated diseases.
