Clinical study of Senggin Xinmaitong capsule in the treatment of non-proliferative diabetic retinopathy
10.3760/cma.j.issn.1008-6706.2016.22.035
- VernacularTitle:参七脉心通胶囊治疗非增殖期糖尿病视网膜病变的临床效果观察
- Author:
Derong MAO
- Publication Type:Journal Article
- Keywords:
Senggin Maixintong capsule;
Traditional Chinese medicine;
Diabetic retinopathy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(22):3496-3499
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical curative effect and mechanism of Senggin Xinmaitong capsule in the treatment of non -proliferative diabetic retinopathy.Methods One hundred and twenty patients with non -prolif-erative diabetic retinopathy were randomly divided into the observation group and control group.The control group was given the standard treatment according to the clinical diagnosis and treatment guidelines for diabetic retinopathy in China in 2014.The observation group was treated with Senggin Xinmaitong capsule on the basis of treatment of the control group.Treatment time was 6 months.Before treatment and after treatment,ELISA method was used to detect serum transforming growth factor beta 1 (TGF - 1 ),interleukin -6 (IL -6)and vascular endothelial cell growth factor (VEGF)levels,and according to the performance of the vision and fundus,the clinical efficacy was observed and compared between the two groups.Results Comparison between before treatment and after treatment,the serum levels of TGF -1,IL -6 and VEGF were[(65.19 ±4.53)μg/L vs.(32.90 ±5.17)μg/L,t =3.905],[(45.18 ± 3.28)pg/mL vs.(24.87 ±7.09)pg/mL,t =3.275],[(175.43 ±21.59)μg/L vs.(109.98 ±10.21 )μg/L,t =3.316]respectively in the observation group,while the levels of TGF - 1,IL -6 and VEGF were [(64.97 ± 5.37)μg/L vs.(50.91 ±4.85)μg/L,t =2.761],[(47.09 ±3.16)pg/mL vs.(35.28 ±5.10)pg/mL,t =2.874], [(168.17 ±28.05)μg/L vs.(147.09 ±12.38)μg/L,t =2.548]respectively in the control group,after treatment, the serum levels of TGF -1,IL -6 and VEGF were decreased in the two groups compared with pre treatment(all P <0.05),and the improvement in the observation group was significantly better than the control group[t value(IL -6, TGF -β1,VEGF)=3.031,3.003,3.006,all P <0.05].The clinical efficacy of the observation group was better than the control group,the difference was statistically significant (90.00% vs.73.33%,χ2 =2.872,P <0.05 ). Conclusion The Senggin Xinmaitong capsule can significantly improve the clinical symptoms of patients with non -proliferative diabetic retinopathy,increase the visual acuity level and down -regulation of inflammatory reaction,inhi-bition the level of VEGF,thus to delay the progression of the disease.
