Progress of molecular targeted therapy in the treatment for recurrent epithelial ovarian cancer

VernacularTitle:分子靶向治疗在复发性上皮性卵巢癌中的研究进展
Author: Qin ZHANG ; Min QIAN ; Qun GUAN ; Qi LIU
Publication Type:Journal Article
Keywords: Targeted therapy; Epithelial ovarian cancer; Recurrent
From: Journal of Medical Postgraduates 2016;29(10):1116-1120
CountryChina
Language:Chinese
Abstract: Epithelial ovarian cancer is the most lethal gynecologic malignancy, drug?resistance will eventually appear after re?peated intermittent chemotherapy. However, second?line chemotherapy only works on a few patients, new drugs with better efficacy and less side effects are needed. There are a number of promising results of molecular targeted therapy in recent clinical trials for patients with recurrent epithelial ovarian cancer, such as Bevacizumab, Olaparib, Pazopanib, etc. They have been demonstrated to improve progression?free survival of patients with platinum?resistant ovarian cancer, which might become a new strategy for such patients. In this review, we summarized the current status and progress of targeted therapy for recurrent epithelial ovarian cancer.