The clinical values of extracapsular invasion at sentinel lymph nodes on prognostic evaluation of patients with breast cancer
10.3760/cma.j.issn.1008-6706.2016.21.023
- VernacularTitle:前哨淋巴结包膜外侵犯在乳腺癌患者预后评估中的价值
- Author:
Mao LI
;
Ming GUAN
;
Cheng SI
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Sentinel lymph nodes;
Biopsy;
Prognosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(21):3291-3293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical values of extracapsular invasion at sentinel lymph nodes in patients with breast cancer.Methods From Jan,2010 to Jan,2013,80 patients underwent axillary lymph node dissection due to sentinel lymph nodes invasion were enrolled in this prospective study.Patients were signed to extracapsular at sentinel lymph nodes positive group (n =45)and control group (n =35)according to the intra -operative pathology.The primary outcome was rate of positive non -sentinel lymph nodes and the second outcomes were 3 -year recurrence -free survival,mortality and health -related quality of life.Results Compared with the control group,the patients in extracapsular at sentinel lymph nodes positive group got a significantly higher rate of positive non -sentinel lymph nodes (91.11% vs.28.57%,χ2 =33.321,P <0.001 );a significantly lower rate of 3 -year recurrence -free survival(57.78% vs.88.57%,χ2 =9.114,P =0.003);a significantly higher rate of mortality (17.78% vs.2.86%,χ2 =4.390,P =0.036);and a significantly lower level of health -related quality of life[(78.43 ±12.43)vs.(87.54 ±11.89),t =11.324,P =0.000].Conclusion Extracapsular invasion at sentinel lymph nodes was a reliable predictor for non -sentinel lymph nodes invasion and long -term clinical outcomes.
