Mechanism progress of bronchial asthma cured by PPARγagonists
10.3760/cma.j.issn.1008-6706.2016.21.039
- VernacularTitle:过氧化物酶体增殖物活化受体γ激动剂抗支气管哮喘作用机制研究进展
- Author:
Xiaomei ZHOU
;
Yueming ZHANG
;
Li NAN
- Publication Type:Journal Article
- Keywords:
Bronchial asthma;
Peroxisome proliferators -activated receptors;
Molecular mechanisms of pharmacological action
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(21):3352-3354
- CountryChina
- Language:Chinese
-
Abstract:
Peroxisome proliferators -activated receptors γ(PPARγ)agonist is a kind of drugs that is widely used in the treatment of type 2 diabetes,also shows effects on hypertensive disease,regulating blood lipid metabolism, anti -atherosclerosis and inhibiting inflammatory response.In recent years,good effects of PPARγagonist have been found on different animal models of asthma,and production of proinflammatory cytokines can significantly be reduced. Airway remodeling can be reduced,and airway hyper responsiveness can be inhibited by PPARγagonist that provide theoretical basis on new drugs for asthma.The mechanism of bronchial asthma cured by PPARγagonists are reviewed briefly.
