Effect of propofol on the patients under neurally adjusted ventilator assist
10.3760/cma.j.issn.1671-0282.2016.09.015
- VernacularTitle:丙泊酚对神经调节辅助通气患者的影响研究
- Author:
Lei ZHANG
;
Fangchao YAO
;
Bing WANG
;
Yongqiang WANG
- Publication Type:Journal Article
- Keywords:
Propofol;
Sedation;
Neutrally adjusted ventilator assist
- From:
Chinese Journal of Emergency Medicine
2016;25(9):1171-1175
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of different depths of propofol sedation on patients under neurally adjusted ventilator assist (NAVA)ventilation.Methods A total of fifty patients supported by NAVA ventilation admitted from June 2012 to June 2015 into intensive care unit (ICU)were enrolled for prospective study.The patients were randomly divided into light sedation group (n =20)and deep sedation group (n =20).The respiratory mechanics index:peak inspiration pressure (PIP),mean airway pressure (Pmean),electrical activity of the diaphragm (EAdi),gas exchange index,pH value of arterial blood, partial pressure of oxygen (PaO2 ), partial pressure of carbon dioxide (PaCO2 ), patient-ventilator synchrony,trigger delay time,off cycle delay time,hemodynamic indexes,mean arterial blood pressure (MAP),heart rate (HR)of the two groups were detected and documented.Enumeration data were analyzed with χ2 test,measurement data were analyzed with t test,and P <0.05 was considered to be significant.Results The PIP,Pmeam and EAdi under light sedation and deep sedation were lower than those in wakefulness (compared with wakefulness,the t values of PIP,Pmean and EADi under light sedation were 2.519,2.363,2.980,respectively and the t values of those under deep sedation were 3.158, -4.307,4.462,P <0.05).Compared with light sedation,the PIP,Pmeam and EAdi were significant decrease under deep sedation (the t values were 2.018, -2.441,3.402,respectively,P <0.05).There were no significant differences in MAP,HR,PaCO2 between light sedation and before sedation (the t values were 1.620,1.492, -0.267,respectively,P >0.05 ),while under the deep sedation,MAP and HR were lower than those in wakefulness and under light sedation (compared with wakefulness,the t values of deep sedation respectively were 2.805,2.944,and compared with light sedation,the t values of deep sedation were significantly reduced to 2.175,2.019,respectively,P <0.05)and PaCO2 under deep sedation (the t values respectively were -4.644,-0.315,P <0.05)was significant increased compared with light sedation and before sedation.There were no significant difference in pH,PaO2 ,trigger delay,off cycle delay between after sedation and before sedation,and between light sedation and deep sedation (compared with wakefulness,the t values of light sedation were -1.470, 1.250, -0.745, -0.555,respectively,and the t values of deep sedation respectively were -1.090,-0.333, -1.088, -0.717,while compared with light sedation,the t values of deep sedation respectively were -0.612, -0.542,0.379,1.225,P >0.05 ).Conclusions Light sedation of propofol could reduce the EAdi and airway pressure without effect on gas exchange,haemodynamics and patient-ventilator synchrony in the patients under NAVA ventilation.
