Advances in Research on Stem cell-derived exosomes in Ischemic heart disease
10.16571/j.cnki.1008-8199.2016.09.021
- VernacularTitle:干细胞源外泌体在治疗心肌梗死中的作用机制研究进展
- Author:
Ling LI
;
Bei SHI
- Publication Type:Journal Article
- Keywords:
Exosomes;
Stem cell tansplantion;
Myocardial infarction;
microRNA
- From:
Journal of Medical Postgraduates
2016;29(9):987-992
- CountryChina
- Language:Chinese
-
Abstract:
Stem cell therapy provides immense hope for restoring the impaired cardiomyocytes .However, it has been debated on the effectiveness , mechanisms , and survival of the donated cell population in the ischemic myocardial milieu .Protective paracrine effect of stem cells on cardiomyocytes gradually arose great attentions .Exosomes , as typical representative of paracrine effect of stem cells, are 30-100 nm in size and tiny microvesicles released by cells in response to different physiological states , and enriched in pro-teins, messenger RNAs, and miRs characteristic of parental stem cells , represent great potential for treating cardiovascular diseases . Recent studies show that exosomes from different kinds of stem cells can effectively promote cardiac function by means of promoting the donated cell survival , proliferation and angiogenesis in the ischemia heart .The aim of this review is to summarize current research ef-forts on exosomes from different kinds of stem cells , including their potential mechanism to develop a potentially viable therapy for the treatment of impaired cardiomyocytes via promoting cardiomyocytes survival , proliferation and angiogenesis;inhibiting inflammatory re-sponse and cardiac fibrosis after myocardial infarction .
