The value of 18FDG PET-CT in the diagnosis of mediastinal lymph node metastasis in non-small cell lung cancer:a Meta-analysis
10.3760/cma.j.issn.1005-1201.2016.10.005
- VernacularTitle:基于18F-脱氧葡萄糖PET-CT成像对非小细胞肺癌纵隔淋巴结转移识别的Meta分析
- Author:
Lu BAI
;
Nan YU
;
Yan LI
;
Weishan ZHANG
;
Xiaoyi DUAN
;
Youmin GUO
- Publication Type:Journal Article
- Keywords:
Carcinoma,Non-small-cell lung;
Positron-emission tomography;
Lymph nodes;
Meta-analysis
- From:
Chinese Journal of Radiology
2016;50(10):752-757
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the diagnostic value of mediastinal lymph node in non-small cell lung cancer using PET-CT by Meta-analysis. Methods Publications on mediastinal lymph node staging of non-small cell lung cancer by PET-CT published from January 2002 to January 2016 were filtered and assessed according to criteria from the PubMed, EMBASE, Cochrane library database. The number of true positive, false positive, false negative and true negative were extracted, meta-analysis was performed using STATA software, and receiver operating characteristic curve was applied, then area under the curve(AUC) was calculated. At last, heterogeneous sources were discussed and subgroup analyses were performed. Results Twenty-three relevant literatures(2 959 patients) were enrolled, the diagnostic sensitivity and specificity based on the patients were 0.66(0.55—0.75) and 0.84(0.79—0.89), AUC was 0.84 (0.80—0.87). The results of subgroup analysis suggested that pulmonary tuberculosis was one important factor that influenced the PET-CT diagnosis of mediastinal lymph node metastasis in NSCLC patients(P=0.01). Conclusions PET-CT has a high accuracy for the mediastinal lymph node staging in non-small cell lung cancer, and it is the recommendedexamination method in these patients. Patients who had suffered from pulmonary tuberculosis should be treated with caution.
