Key advances in podocyte studies using zebrafish model
10.16571/j.cnki.1008-8199.2016.09.019
- VernacularTitle:斑马鱼在足细胞研究中的应用及其进展
- Author:
Qing HOU
;
Zhaohong CHEN
- Publication Type:Journal Article
- Keywords:
Zebrafish;
Kidney development;
Podocytes
- From:
Journal of Medical Postgraduates
2016;29(9):976-981
- CountryChina
- Language:Chinese
-
Abstract:
Zebrafish have been emerging as a valuable model for kidney research , including podocyte biology , nephrogenesis and kidney disease .The zebrafish kidney has similar structure , common function and the same cell types with human kidney .Rapid development and feasible genetic editing approaches in zebrafish provide an ideal model for high -throughput gene screening involved in kidney disease and developmental process .Loss or injury of podocytes is the key mechanism , which can lead to proteinuria , glomerulo-sclerosis and renal failure .Here, we introduce structure and function of zebrafish kidney , filtration estimating assays , podocytes injury model and the highlights of recent zebrafish podocytes studies .
