Research Review of the Action Mechanism of Acupuncture Based on Cell Apoptosis
10.13460/j.issn.1005-0957.2016.10.1143
- VernacularTitle:基于细胞凋亡探讨针刺作用机理的研究述评
- Author:
Lin CHEN
;
Qiaofeng WU
;
Mingxiao YANG
;
Shufang DENG
;
Lin BAI
;
Liang CHEN
;
Fanrong LIANG
- Publication Type:Journal Article
- Keywords:
Acupuncture;
Cell apoptosis;
Action mechanism;
Literature review
- From:
Shanghai Journal of Acupuncture and Moxibustion
2016;35(10):1143-1146
- CountryChina
- Language:Chinese
-
Abstract:
Apoptosis refers to the programmed death process of cells modulated by genes. It plays an important role in promoting the evolution of organisms, regulating the development of multiple systems, and maintaining the stability of internal environment. The major apoptosis pathways include mitochondrial pathways, death receptor pathways, and endoplasmic reticulum pathways. With the rapid development of the scientific research on acupuncture, it’s revealed that cell apoptosis should be closely related to the action of acupuncture. So far, the major apoptosis factors involved in relevant researches are P53, Bcl-2 family, Cyt-C, Caspase, Fas/Fasl, TNFR1/TNF-?, and FADD-Caspase8, and PERK, etc. Via influencing these apoptosis factors or genes, acupuncture can produce various effects in improving tissue ischemia, protecting neural cells, reducing inflammation, and correcting endocrine disorders. This article summarized and reviewed the apoptosis pathways and key factors related to the action of acupuncture, to provide some beneficial references for future studies.
