Effects of Triamcinolone Acetonide on Choroidal Neovascularization in Brown Norway Rats
10.3969/j.issn.1006-9771.2016.10.009
- VernacularTitle:曲安奈德对棕色挪威大鼠脉络膜新生血管生长的影响
- Author:
Xiaoyan GAO
;
Shouzhi HE
- Publication Type:Journal Article
- Keywords:
triamcinolone acetonide;
nuclear factor-kappa B;
choroidal neovascularization;
brown Norway rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2016;22(10):1154-1158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of intravitreal triamcinolone acetonide injection on choroidal neovascularization in brown Norway rats. Methods Thirty-six healthy brown Norway rats were divided randomly into control group (n=18) and experimental group (n=18), while one eye was chosen randomly as experimental eye. The choroidal neovascularization model was establishied, while 8μl triamcin-olone acetonide was injected in vitreous body immediately after photocoagulation in the experimental group, and the same volume isotonic balanced salt solution was injected in the control group. The eyes of six rats were enucleated for histological slices in the second, forth, and sixth week, respectively. The expression of nuclear factor-kappa B was detected with immunohistochemical method, and the max area of choroidal neovascularization was also measured. Results The area of choroidal neovascularization was smaller, and the expression of nucle-ar factor-kappa B was lower in the experimental group than in the control group (t>7.450, P<0.001). Conclusion Triamcinolone acetonide could effectively inhibit the development of choroidal neovascularization, and decrease the expression of nuclear factor-kappa B in brown Norway rats.
