Comparative Study of Focal Cerebral Ischemia Model Based on Middle Cerebral Artery Occlusion with Suture-occluded Method in Rats (review)
10.3969/j.issn.1006-9771.2016.10.017
- VernacularTitle:基于线栓法大鼠大脑中动脉闭塞的局灶性脑缺血模型的比较研究
- Author:
Pei MIAO
;
Tong ZHANG
;
Haixia MI
- Publication Type:Journal Article
- Keywords:
suture-occluded method;
focal cerebral ischemia model;
middle cerebral artery occlusion;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2016;22(10):1190-1195
- CountryChina
- Language:Chinese
-
Abstract:
There are many ways to prepare middle cerebral artery occlusion (MCAO) rat model. The focal cerebral ischemia model es-tablished by the suture-occluded method is widely accepted as an ideal focal cerebral ischemia model, which can be used in the basic and clinical study of cerebral vascular diseases. However, it still has the defects of high technical requirement, large model difference and high animal mortality. A variety of focal cerebral ischemia models were established by changing the retention time of the thread, the road the thread plugging into, the type of thread bolt and the depth of the thread plugging. This article compared different suture-occluded method, as well as the suture-occluded method to other modeling methods, different cerebral ischemia models may be different in the pathophysiology of cerebral infarction, and the effects may also be different.
