Evaluation of Fractional Flow Reserve Determined by CT Coronary Angiography in Relevant Patients
10.3969/j.issn.1000-3614.2016.09.003
- VernacularTitle:计算机断层摄影术冠状动脉造影对血流储备的评价
- Author:
Di FAN
;
Guangbin CUI
;
Qiang LI
;
Jia ZHU
;
Wei WANG
;
Guozhi XIA
;
Yu XIANG
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Tomography,X-ray computed;
Fractional lfow reserve,myocardial;
Coronary angiography
- From:
Chinese Circulation Journal
2016;31(9):840-843
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the accuracy and clinical value of fractional lfow reserve (FFR) determined by CT coronary angiography (CTA) in relevant patients. Methods: A total of 43 patients treated in our hospitals from 2013-10 to 2015-10 were retrospectively studied. There were 29 (67.40%) with male gender, the average age was (60.2±10.1) years. The patients received CTA at 1 week prior coronary angiography (CAG), the interval between CTA and CAG was (5.4±1.6) days. FFR was measured by both CAG and CTA (FFRCT) in selected target vessel which was deifned as maximal diameter reduction 50% to 70%. The imaging data were recorded and compared, FFRCT was calculated. Results: 48 vessels from 43 patients were eligible for analysis as target vessels. FFRCT vas evaluated based on the gold criteria of FFR. FFRCT had the diagnostic accuracy at 83.3%, sensitivity 75.0%, speciifcity 89.3% and positive predictive value was 83.3%, negative predictive value was 83.3% respectively. FFR and FFRCT showed obvious correlation (r=0.704,P<0.001); Bland-Altman analysis presented good concordance with 95% limits of agreement for FFRCTand FFR value ranged from -0.12 to 0.16, and 95.8% of the points (46/48) fell in the 95% limit of agreement, Receiver operating characteristic curve indicated that AUC of FFRCT was 0.871 (95% CI 0.770-0.973). Conclusion: CTA could accurately assess FFR, and FFRCT might be used in guiding the treatment for patients with intermediate coronary stenosis in clinical practice.
