Correlation Study of Galectin-3 and Soluble ST2 Levels in Heart Failure Diagnosis
10.3969/j.issn.1000-3614.2016.09.009
- VernacularTitle:半乳糖凝集素-3、可溶性基质溶素-2检测对心力衰竭诊断的相关性研究
- Author:
Xiaoxiao XU
;
Ruyi JIA
;
Tao WANG
;
Qiang LIU
;
Zhen ZHEN
- Publication Type:Journal Article
- Keywords:
Heart failure;
Galectin-3;
Soluble ST2;
N-terminal brain natriuretic peptide;
Diagnosis
- From:
Chinese Circulation Journal
2016;31(9):866-869
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the correlations between galectin-3, soluble ST2 (sST2) levels and chronic heart failure (CHF) classiifcation, traditional HF indicator and short-term death in relevant patients. Methods: This research included 2 groups: CHF group, containing 142 relevant patients treated in our hospital from 2014-02 to 2015-10 and Control group, containing 85 normal subjects from physical examination at the same period of time. Based on NYHA criterion, the patients were classiifed in NYHA grade II, III and IV respectively. Blood levels of N-terminal brain natriuretic peptide (NT-ProBNP), high-sensitivity C reactive protein (hs-CRP) and ultrasonic morphology were examined upon admission; protein expressions of galectin-3 and sST2 were assessed by ELISA. Results: The patients with NYHA grade III and IV had increased levels of galectin-3 and soluble sST2; galectin-3, sST2 were positively related to NT-ProBNP, hs-CRP and LVEDD, while negatively related to LVEF. Logistic regression analysis indicated that galectin-3 and sST2 were related to short-term death in CHF patients,P<0.05. Area under ROC curve of galectin-3 and sST2 for diagnosing CHF were 0.738 and 0.771,P<0.01. Conclusion: Galectin-3 and sST2 levels were related to traditional HF indicator and could be used for CHF diagnosis in relevant patients.
