Effect and mechanism of application in canicular days plus enteral nutrition for cough variant asthma in kids
10.1007/s11726-016-0945-z
- VernacularTitle:三伏灸配合肠内营养治疗儿童咳嗽变异性哮喘的效应与机制研究
- Author:
Su ZHENG
;
Qiang LUO
;
Li PENG
;
Jing XU
;
Jingping MU
- Publication Type:Journal Article
- Keywords:
Moxibustion Therapy;
Cough;
Asthma;
Enteral Nutrition;
Randomized Controlled Trials;
Respiratory Function Tests;
Child
- From:
Journal of Acupuncture and Tuina Science
2016;14(5):333-339
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the clinical efficacy of application in canicular days plus enteral nutrition in treating cough variant asthma (CVA) in kids, and to explore its action mechanism. Methods:Following a randomized controlled single-blind parallel-group design, 138 eligible kids with CVA were randomized into an observation group, a canicular-day application group, and an enteral nutrition group, 46 kids in each group. The canicular-day application group was intervened by application in canicular days, the enteral nutrition group was by enteral feeding, and the observation group was by both canicular-day application and enteral feeding. The therapeutic efficacies were evaluated after a treatment course. Results: The recovery rate and total effective rate were respectively 50.0% and 98.0% in the observation group, versus 23.9% and 91.3% in the canicular-day application group, and 13.0% and 78.6% in the enteral nutrition group. The observation group was significantly superior to the other two groups (bothP<0.05). In comparing the global symptom score, peak expiratory flow (PEF), forced expiratory volume in one second (FEV1), CD3+, CD4+, CD4+/CD8+, CD8+, hemoglobin (Hb), total protein (TP), albumin (ALB), eosinophil cationic protein (ECP), lipid peroxide (LPO), leukotriene (LT), body weight (BW), triceps skin-fold (TSF), and arm muscle circumference (AMC), the observation group was significantly better than the other two groups (bothP<0.05). Conclusion:Application in canicular days plus enteral nutrition can significantly improve the pulmonary function and symptoms in children’s CVA, and the effect is possibly produced by regulating cellular immune system, enhancing Hb, TP, ALB, BW, TSF, AMC, and inhibiting the production of ECP, LPO, and LT.
