Evaluation of Cardiopulmonary Exercise Testing on Sildenafil Effect for Treating the Patients With Pulmonary Arterial Hypertension
10.3969/j.issn.1000-3614.2016.09.013
- VernacularTitle:心肺运动试验对评估肺动脉高压患者西地那非药物效果的作用
- Author:
Yi TANG
;
Zhihong LIU
;
Chenhong AN
;
Xiuping MA
;
Changming XIONG
;
Xinhai NI
;
Qin LUO
;
Zhihui ZHAO
;
Qing ZHAO
;
Hongliang ZHANG
;
Yong WANG
;
Zhiwei HUANG
;
Qi JIN
- Publication Type:Journal Article
- Keywords:
Hyperteusion,pulmonary;
Sildenaifl;
Cardiopulmonary exercise testing
- From:
Chinese Circulation Journal
2016;31(9):881-884
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate cardiopulmonary exercise testing (CPET) on sildenaifl effect for treating the patients with pulmonary arterial hypertension (PAH). Methods: A total of 25 PAH patients received sildenaifl treatment in our hospital from 2012-01 to 2014-01 were enrolled as PAH group, in addition, there were a Control group including 24 healthy subjects. The CPET, echocardiography, NYHA function class, 6-mimute walking distance (6MWD) and plasma levels of NT-proBNP at the baseline, (6-12) months and (13-18) months after sildenaifl treatment were assessed and compared between 2 groups. Results: Compared with Control group, PAH group showed decreased aerobic capacity (peakVO?2, Peak O2pulse) and ventilation efifciency (PETCO2@AT, VE?/VC?O2@AT), allP<0.05. At (8±2) months after sildenaifl treatment, aerobic capacity and ventilation efifciency was improved, meanwhile, NYHA function class, 6MWD and plasma levels of NT-proBNP were improved, allP<0.05. At (16±2) months after sildenaifl treatment, 6MWD was similar,P=0.26, while peak VO?2 and peak O2 pulse were decreased than they were at (8±2) months after sildenaifl treatment,P=0.04 and 0.06; the ventilation efifciency was elevated (as presented by increased VE?/VC?O2@AT and decreased PETCO2@AT,P=0.04 and P=0.04); plasma level of NT-proBNP was increased,P=0.05. Conclusion: CPET can effectively evaluate sildenaifl effect for treating PAH patients and therefore and guide the drugs therapy.
