Roles of Hippo-TAZ signaling pathway in breast cancer and breast cancer stem cells
10.3760/cma.j.issn.1673-422X.2016.10.014
- VernacularTitle:Hippo-TAZ 信号通路在乳腺癌及乳腺癌干细胞中的作用
- Author:
Bing YAN
;
Ying LU
;
Chunying ZHANG
;
Qing LI
;
Jun MAO
;
Lianhong LI
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Neoplastic stem cells;
Hippo signaling;
Transcriptional co-activator with PDZ-binding motif
- From:
Journal of International Oncology
2016;43(10):779-782
- CountryChina
- Language:Chinese
-
Abstract:
Hippo signaling pathway plays an important role in the regulation of organ growth,tissue regeneration,tumor occurrence and development.Transcriptional co-activator with PDZ-binding motif (TAZ)is the downstream transcription factor of Hippo signaling,participates in the regulation of the entire signaling path-way.In recent years,many studies have found that over-expression of TAZ has a close relationship with the oc-currence,development and prognosis of breast cancer.Discussing the relationship of Hippo-TAZ with breast cancer and breast cancer stem cells may provide a new way for breast cancer diagnosis and treatment.
