Correlation of serum homocysteine,vitamin B12 and folate levels and subclinical hypothyroidism in pregnancy
10.3969/j.issn.1671-8348.2016.27.013
- VernacularTitle:血清同型半胱氨酸、维生素B 12和叶酸水平与妊娠期亚临床甲状腺功能减退的相关性
- Author:
Ling ZHANG
;
Liang SHI
;
Jie ZHANG
- Publication Type:Journal Article
- Keywords:
vitamin B12;
folic acid;
hypothyroidism;
pregnant women;
homocysteine
- From:
Chongqing Medicine
2016;45(27):3785-3787
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the correlation of Serum homocysteine ,vitamin B12 and folate levels and subclinical hypot‐hyroidism in pregnancy .Methods 150 cases of subclinical hypothyroidism during pregnancy were selected as the experimental group ,and 150 cases of pregnant women with normal thyroid function were collected as the control group .Compared the serum thy‐roid‐stimulating hormone ,free thyroid hormones ,three free triiodothyronine ,homocysteine ,serum vitamin B12 ,folic acid levels of pregnant women in the two groups ,and analyzed the related serum markers of thyroid‐stimulating hormone and serum homocys‐teine .Results The homocysteine levels in experimental group was higher than that of control group(P<0 .05) ,the vitamin B12 and folate levels in experimental group were lower than that of control group (P<0 .05) ,the thyroid‐stimulating hormone levels in ex‐perimental group was significantly higher than that of control group (P<0 .05) .Serum thyroid‐stimulating hormone and homocys‐teine levels were positively correlated (P<0 .05) ,serum thyroid‐stimulating hormone and vitamin B12 and folic acid had no signifi‐cant correlation (P>0 .05) .Serum homocysteine and thyroid stimulating hormone levels were positively correlated (P<0 .05) ,ser‐um homocysteine and folate levels were negatively correlated (P<0 .05) ,serum homocysteine levels and vitamin B12 were not corre‐lated (P> 0 .05) .Conclusion Subclinical hypothyroidism during pregnancy have some relevance with homocysteine ,vitamin B12 and folate levels .
