Effects of narrow-band ultraviolet B radiation on the efficacy of autologous epidermal grafting for vitiligo
10.3760/cma.j.issn.0412-4030.2016.10.013
- VernacularTitle:窄谱中波紫外线照射对白癜风自体表皮移植的作用研究
- Author:
Yongjian SHI
;
Yuanyuan LIU
;
Ying LIU
- Publication Type:Journal Article
- Keywords:
Vitiligo;
Ultraviolet rays;
Interleukin-18;
Tumor necrosis factor-alpha;
Cell adhesion molecules;
Autologous epidermal grafting
- From:
Chinese Journal of Dermatology
2016;49(10):728-731
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of autologous epidermal grafting combined with narrow?band ultraviolet B(NB?UVB)radiation for the treatment of vitiligo, and to explore their possible action mechanisms. Methods Totally, 30 patients with vitiligo were randomly and equally divided into 2 groups:epidermal grafting group treated with autologous epidermal grafting alone, and combination group treated with both autologous epidermal grafting and NB?UVB radiation. Fifteen healthy volunteers served as the healthy control group. Enzyme?linked immunosorbent assay(ELISA)was performed to detect the levels of interleukin?18(IL?18), tumor necrosis factor?α(TNF?α)and soluble intercellular adhesion molecule?1 (sICAM?1) in interstitial fluid from the patients before and after the treatment, as well as from the healthy controls. Therapeutic effects were evaluated after 3?month treatment. Results Before the treatment, the epidermal grafting group and combination group both showed significantly increased levels of IL?18(0.985 ± 0.305μg/L, 1.008 ± 0.399μg/L, respectively), TNF?α(1.132 ± 0.313μg/L, 1.147 ± 0.474μg/L, respectively)and sICAM?1(1.215 ± 0.284μg/L, 1.221 ± 0.432μg/L, respectively)in interstitial fluid compared with the healthy control group(all P<0.01). The levels of the three cytokines in the combination group almost all returned to normal after the 3?month treatment. In addition, the combination group showed a significantly higher response rate compared with the epidermal grafting group(68.9%vs. 43.8%, P<0.05). Conclusion Immune abnormalities exist in local lesions of patients with vitiligo, and NB?UVB radiation can increase the success rate of epidermal grafting likely by regulating the body′s immune function.
