Anticancer effect and mechanism of miR-139
10.3760/cma.j.issn.1673-422X.2016.10.010
- VernacularTitle:miR-139抗肿瘤作用与机制
- Author:
Junshan ZHAI
;
Nan LI
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Neoplasms;
Target gene
- From:
Journal of International Oncology
2016;43(10):765-768
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA)is closely related to the occurrence and development of neoplasms. miR-139 is a tumor-suppressive miRNA and its expression is decreased in a variety of tumor tissues,while over-expression of miR-139 can inhibit cancer cell proliferation,migration,invasion and induce cell apoptosis by suppressing the expression of multiple kinds of target genes.Therefore,miR-139 has potential applications in tumor diagnosis,treatment and prognosis assessment.
