Expression and role of microtubule-associated protein in breast cancer
10.3760/cma.j.issn.1673-422X.2016.10.015
- VernacularTitle:微管相关蛋白在乳腺癌中的表达及作用
- Author:
Sanqian HUANG
;
Jing LI
;
Zhihong LIU
;
Liang ZENG
- Publication Type:Journal Article
- Keywords:
Microtubule-associated proteins;
Breast neoplasms
- From:
Journal of International Oncology
2016;43(10):783-786
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,many new microtubule-associated proteins are found or studied extensively in the treatment of breast cancer.End-binding protein 1 (EB1)has the promotional effects on cell proliferation and enhances the carcinogenesis of breast cancer,and also can affect the chemosensitivity of the treatment. MAP7 domain-containing protein 3 (Mdp3)expresses in breast epithelial cells and plays an important role on the growth and metastasis.Nucleolar and spindle-associated protein (NuSAP)gene is up-regulated in breast cancer and is considered as a biomarker for breast cancer.Tau expression level has a strong correlation with estrogen receptor (ER),progesterone receptor (PR)and human epidermal growth factor receptor-2 (HER-2), and it remains controversial in the results of the effect of paclitaxel chemotherapy and hormone treatment.
