Progress in self-renewal signal pathways of liver cancer stem cells and potential targets for therapy
10.3867/j.issn.1000-3002.2016.09.010
- VernacularTitle:肝癌干细胞自我更新信号转导及作为潜在治疗靶点的研究进展
- Author:
Helei XU
;
Chunqi WU
;
Yansheng DONG
;
Man LI
;
Lihua XIE
;
Quanjun WANG
;
Xisha WANG
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
liver neoplasms;
stem cells;
signal transduction
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(9):967-974
- CountryChina
- Language:Chinese
-
Abstract:
There is emerging evidence from clinical studies that the existence of liver cancer stem cells(CSCs)or tumor initiating cells is responsible for the high recurrence rates of tumor,generation of metastasis,and resistance to therapeutic regimens after therapy. Here,the characteristics of liver CSCs,clinical manifestation,molecular signaling Wnt/β-catenin,signal transducers and activators of transcription 3,NANOG,annexin A3/c-Jun N-terminal kinase,and chapter four-transmembrane 4 L six family member 5/CD44 in liver CSC self-renewal were briefly reviewed. In addition,potential targets for drug therapy were analyzed,providing some reference for drug discovery that selectively target liver CSC self-renewal signals.
