Progress in microbiome and its application to pharmacological and toxicological research of traditional Chinese materia medica
10.3867/j.issn.1000-3002.2016.09.011
- VernacularTitle:肠道微生物组及其在中药药理毒理研究中的应用
- Author:
Hong DENG
;
Chunqi WU
;
Tao JIANG
;
Quanjun WANG
- Publication Type:Journal Article
- Keywords:
microbiome;
gut;
traditional Chinese materia medica;
pharmacology;
toxicology
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(9):975-982
- CountryChina
- Language:Chinese
-
Abstract:
Microbiome is a novel research field related to human health,agriculture,bio-energy and the environment. Gut microbiome has received much attention from researchers recently. Studies have shown that gut flora is related to some diseases,such as digestive disease(inflammatory bowel disease),metabolic disease(type 2 diabetes), cardie-cerebral vascular disease(Parkinson disease). Traditional Chinese materia medica(TCMM) has long been used as a tonic and taken in a large amount. Gut flora has an effect on pharmacology and toxicology of TCMM after entering the gastroin?testinal tract. This article is intended to review recent researches on microbiome,common detection techniques and the relationship with hepatotoxicity induced by Polygonum multiflorum Thunb.,scutel?laria baicalensis that directly affects the intestinal tract,nephrotoxicity induced by Rhizoma Alismatis and pneumonia induced by Xiao-Chaihu-Tang.
