GADD45αin genotoxicity test:molecular principles and research progress
10.3867/j.issn.1000-3002.2016.09.013
- VernacularTitle:GADD45α在遗传毒性检测中的分子原理及研究进展
- Author:
Jin XI
;
Xi CHAO
;
Liu KAI
;
Liu JIN
- Publication Type:Journal Article
- Keywords:
GADD45α;
DNA damage;
cell cycle;
genotoxicity test
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(9):989-996
- CountryChina
- Language:Chinese
-
Abstract:
As a member of growth arrest and DNA damage inducible gene family,GADD45αparticipats in the regulation of cell cycle,cell senescence,cell survival and apoptosis. GADD45αplays a critical role in the responses to cell injury induced by a variety of factors including cell stress and genotoxic chemicals. Different transcription factors and proteins are involved in transcriptional regulation of GADD45αgene. GADD45αprotein has been implicated in the regulation of genomic stability related cellular responses through interaction with other proteins. Genotoxicity test systems based on the char?acteristics of GADD45α in regulation of cell function,can be applied to the detection of potentially genotoxic compounds,which provides new ideas and methods about genotoxicity assessment. The molecular mechanism and research progress of GADD45α in genotoxicity test are summarized in this article.
