Uncoupling protein 2 in regulatory mechanisms and basical experiments
10.3760/cma.j.issn.1673-4408.2016.09.010
- VernacularTitle:解偶联蛋白2调控机制及实验研究进展
- Author:
Yiting CHEN
;
Qiyi ZENG
- Publication Type:Journal Article
- Keywords:
Uncoupling protein 2;
Mitochondria;
Reactive oxygen species;
Sepsis
- From:
International Journal of Pediatrics
2016;43(9):700-703
- CountryChina
- Language:Chinese
-
Abstract:
Uncoupling protein 2(UCP2)is a proton transporter which presents in the mitochondrial inner membrane. Recent studies have found that UCP2 plays important roles in protecting mitochondria functions,re-ducing mitochondrial ROS generation by inducing proton leak across the inner mitochondrial membrane and pro-moting mild uncoupling which leading to a decrease in the mitochondrial inner membrane′s potential. Because of its antioxidant function,UCP2 has been studied in several domains. This review provides novel insights into the molecular mechanisms,by which the activity of UCP2 is regulated and describe novel findings concerning basical experiments of UCP2.
