Advances in relationship between plexinC1 and lung diseases
10.3760/cma.j.issn.1673-4912.2016.09.011
- VernacularTitle:PlexinC1与肺部疾病的研究进展
- Author:
Zhen ZHOU
;
Zhenghui XIAO
- Publication Type:Journal Article
- Keywords:
PlexinC1;
Semaphorin 7A;
Lung diseases
- From:
Chinese Pediatric Emergency Medicine
2016;23(9):621-625
- CountryChina
- Language:Chinese
-
Abstract:
PlexinC1 is a large transmembrane protein widely distributed,which belongs to receptor system. PlexinC1 is expressed by monocyte,T-cells,B-cells,dendritic cells,neutrophils,and platelets. Recent researches showed that plexinC1 was intensely associated with lung injury,asthma and pulmonary fibrosis. PlexinC1 binded to its corresponding ligand and activated cellular signal pathway,which then participating in pathophysiologic processes of diseases mentioned above. Reasonably,PlexinC1 influences the development, prognosis of lung diseases and would provide a new target in control and treatment of lung diseases. This pa-per reviewed simply the formation,distribution,function of plexinC1 and the role of it playing in the associat-ed lung diseases.
