Anti-myeloma STAT3 inhibitors and discovery strategies
10.3969/j.issn.1005-1678.2016.08.001
- VernacularTitle:抗多发性骨髓瘤的STAT3抑制剂及其研究策略
- Author:
Xinliang MAO
- Publication Type:Journal Article
- Keywords:
STAT3 signaling pathway;
multiple myeloma;
drug discovery;
high throughput screen
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(8):1-5
- CountryChina
- Language:Chinese
-
Abstract:
The STAT3 protein is a key transcription factor that delivers extracellular signals into nuclei in which it binds to a specific recognition element on DNA sequences and thus regulates the transcription of its target genes.STAT3 is almost expressed in all tissues and cells, therefore, it is extensively involved in both normal and aberrant cellular activities.For example, STAT3 plays an essential role in inflammatory reaction and tumorigenesis.STAT3 has been established as a therapeutic target of various cancers including multiple myeloma,a hematological malignancy from plasma cells.Some STAT3 inhibitors have been developed and extensively studied.In this article, we review the roles of STAT3 in multiple myeloma.The advances and strategies in the development of STAT3 inhibitors are also being discussed.
