Research progress of small molecule inhibitors targeting PI3K-Akt-mTOR pathway
10.3969/j.issn.1005-1678.2016.08.002
- VernacularTitle:PI3 K-Akt-mTOR通路及其小分子抑制剂的研究进展
- Author:
Qiaojun HE
;
Xiaowu DONG
;
Hong ZHU
;
Yongzhou HU
;
Bo YANG
- Publication Type:Journal Article
- Keywords:
PI3K-Akt-mTOR pathway;
small molecular inhibitor;
cancer
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(8):6-15
- CountryChina
- Language:Chinese
-
Abstract:
Aberrant activation of the phosphatidylinositol 3-kinase(PI3K)-protein kinase B(PKB,Akt)-mammalian target of rapamycin(mTOR) pathway is commonly observed in human cancer and is critical for cell survival, proliferation and differentiation.A variety of small molecule inhibitors targeting PI3K-Akt-mTOR pathway are under clinical studies.This review will summarize the recent studies in terms of the PI3K-Akt-mTOR signaling pathway and cancer,research progress of the antitumor activity possessed by PI3K-Akt-mTOR inhibitors,as well as the recent research in the related field conducted by our group.
