Comparison of curative effects of GnRH-a and mifepristone in treatment of endometriosis after laparoscopic operation
10.3969/j.issn.1005-1678.2016.08.019
- VernacularTitle:米非司酮及GnRH-a对子宫内膜异位症术后患者的疗效比较
- Author:
Wei LI
;
Ningjie LU
- Publication Type:Journal Article
- Keywords:
endometriosis;
laparoscopy;
mifepristone;
GnRH-a
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(8):76-78
- CountryChina
- Language:Chinese
-
Abstract:
0bjective To compare the curative effects of GnRH-a and mifepristone in treatment of endometriosis after laparoscopic operation.Methods 114 cases of patients were selected from March 2012 to December 2014 in our hospital with endometriosis after laparoscopic surgery,randomly divided into mifepristone group,GnRH-a group and untreated group,each group for 38 cases.mifepristone group were treated by oral mifepristone one week after operation,25 mg,qd,continuing to take 6 months;GnRH-a group,post operative 1 week received injection of GnRH-a (Tamiflu)3.75 mg,once every 4 weeks,6 times in a row;The untreated group,fails to drug treatment.To compare the symptoms,relapse rate pregnancy rate and serum hormones including FSH, LH and E2 levels.Results After treatment, the total effective rate of GnRH-a and mifepristone group is significantly higher than the untreated group(P<0.05),and the recurrence rate is lower than the untreated group(P <0.05),the pregnancy rate is higher than the untreated groups(P<0.05).The recurrence rate,the remission rate and the pregnancy rate of mifepristone group are lower than the untreated group,there was no statistical significance.Conclusion Mifepristone and GnRH-a can both,effectively reduce the recurrence rate after EMT laparoscopic surgery,can guarantee the pregnancy rate,reduce the adverse reaction.
