Effect of intravenous injection of tranexamic acid on hemorrhage in minimally invasive surgery of total hip arthroplasty
10.3969/j.issn.1005-1678.2016.08.020
- VernacularTitle:静脉注射氨甲环酸对微创人工全髋关节置换出血的效果
- Author:
Hongliu WANG
;
Chaofan MAO
- Publication Type:Journal Article
- Keywords:
tranexamic acid;
total hip arthroplasty;
prevention of postoperative bleeding
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(8):79-81
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of intravenous injection of tranexamic acid on reducing bleeding effect in invasive total hip replacement.Methods In our hospital from April 2015 to April 2016, 50 cases of total hip joint replacement patients as the object of study, patients were randomly divided into observation group and control group, 25 cases in each group.The control group were injected with 0.9% NaCl injection;observation group received intra-articular injection of tranexamic acid after suture, the transfusion volume of blood, complications, hemoglobin concentration, and rate of blood transfusion were compared between the two groups.Results The rate of blood transfusion in the control group was 52.0%, significantly higher than that of the observation group (24.0%), and the difference was statistically significant (χ2 =4.16, P<0.05).The drainage (260.1 ±78.6) mL and transfusion volume (230.8 ±60.1) mL in observation group were better than control group (370.04 ±56.2)mL and (380.2 ±40.6)mL,with statistical significance (P <0.05).The hemoglobin concentration in observation group was lower than control group(P <0.05).There were 2 cases of hematoma, 5 cases of paining in observation group and 3 cases of hematoma, 6 cases of paining in control group, with no statistical significance (χ2 =0.368, P>0.05).Conclusion Tranexamic acid is the main method for prevention of postoperative bleeding, but could not reduce postoperative complications.
