Clinical effect and possible mechanism of Yiqi Shuxin pills in the treatment with viral myocarditis
10.3969/j.issn.1005-1678.2016.08.024
- VernacularTitle:益气舒心丸治疗病毒性心肌炎的效果及可能机制
- Author:
Jijia WANG
;
Yue ZHAO
;
Jingyao LI
;
Hua XU
- Publication Type:Journal Article
- Keywords:
Yiqi Shuxin pills;
Viral myocarditis;
Cellular immunity;
MiR
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(8):91-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and mechanism of Yiqi Shuxin pills in the treatment with viral myocarditis(VMC).Methods 56 cases of VMC in our hospital were randomly divided into the experimental group and the control group,28 cases in each group.The patients in the control group were with routine treatment,and these in the experimental group were treated with Yiqi Shuxin pills based on the control group.The clinical effects between the two groups were compared, and the changes of miR, myocardial enzyme spectrum and immunity were compared before and after treatment.Results The total effective rate was 92.86% in the experimental group and was 72.57% in the control group,there was statistical significance between the two groups(P<0.05);There was no significant difference between the two groups before treatment at miR-1,miR-133,miR-21,CK-MB, cTnI,LDH,CD3 +,CD4 +,CD8 +,NK in serum;The content of miR-1,miR-133,CD3 +,CD4 +,CD8 +,NK after treatment in the two groups were higher than before treatment(P <0.05),miR-21,CK-MB,cTnI and LDH were lower than before(P <0.05);The improvement of these indicators in the experimental group was superior to that in the control group(P<0.05).Conclusion Yiqi Shuxin pills could improve the therapeutic effect of VMC,the mechanism maybe related to improving the circulation of blood miR and enhance cellular immune function.
