Recent progress of aptamer inhibitors targeting c-Met
10.3969/j.issn.1005-1678.2016.08.004
- VernacularTitle:c-Met适配体抑制剂的研究进展
- Author:
Shengqun OUYANG
;
Bo HU
;
Yuqing MIAO
;
Suiyi WU
;
Lianghua WANG
;
Wenxing QIN
- Publication Type:Journal Article
- Keywords:
c-Met;
inhibitor;
targeted oncotherapy;
aptamers
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(8):22-26
- CountryChina
- Language:Chinese
-
Abstract:
c-Met is one member of the receptor tyrosine kinases (RTKs).It is closely related between the over-expression of c-Met and a wide variety of tumor occurrence, development, invasion, metastasis, prognosis and drug resistance.Therefore, c-Met is a potential target for oncotherapy, and researches on its inhibitors have become a hot spot in the field of tumor treatment.Aptamers targeting c-Met are gained from systematic evolution of ligands by exponential enrichment (SELEX).They can bind to c-Met with high specificity and affinity, resulting in the activation or inhibition of c-Met.We envision that anti-c-Met aptamers would be ideal new c-Met inhibitors after optimization, and could be developed into potential targeted drugs for cancers.
