Influence of dexamethasone on alveolar macrophage differentiation in respiratory syncytial virus infected mice
10.3969/j.issn.1005-1678.2016.08.005
- VernacularTitle:地塞米松对呼吸道合胞病毒感染小鼠肺泡巨噬细胞分化的影响
- Author:
Qian HUANG
;
Li WANG
;
Xiaonan LI
- Publication Type:Journal Article
- Keywords:
dexamethasone;
respiratory syncytial virus;
macrophage
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(8):27-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of dexamethasone on M1 BMDM and alveolar macrophage differentiation in respiratory syncytial virus ( RSV) infected mice.Methods Culture M1 BMDM and identify its phenotype, observe the effect of DEX on its transcription factors and cytokines; In RSV infected mice, observe the influence of DEX on the transcription factors and cytokines of alveolar macrophage.Results DEX can inhibit IL-6, IL-12, iNOS and IRF5 expression, but promote IL-10, Arginase-1 and IRF4 expression in M1 BMDM and alveolar macrophages of RSV infected mice, made M1 macrophages transform to M2 macrophages.Conclusion DEX can transform M1 macrophages to M2 macrophages in vivo and in vitro, and inhibit inflammation, this may be one of the mechanism of DEX in the treatment of RSV infection.
