Roles of skeletal muscle growth factors, myosin, and collagen in the repair of injured skeletal muscle
10.3969/j.issn.2095-4344.2016.37.019
- VernacularTitle:骨骼肌生长因子、肌球蛋白及骨骼肌胶原与骨骼肌的损伤与修复
- Author:
Jian FENG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(37):5602-5608
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Regeneration and repair of injured skeletal muscle are influenced by a variety of factors. Skeletal muscle myosin heavy chain and skeletal muscle col agen content are known to be involved in the repair of injured skeletal muscle.
OBJECTIVE:To summarize the changes and roles of skeletal muscle growth factors, myosin, and col agen in the repair of injured skeletal muscle.
METHODS:A computer-based online search was conducted in PubMed and Wanfang databases from 2002 to 2015 to screen the relevant literatures. Roles of skeletal muscle growth factors, myosin, and col agen in the repair of injured skeletal muscle was summarized by col ecting the data regarding the factors influencing exercise and the repair of injured skeletal muscle, and growth factors involved in the regeneration and repair of injured skeletal muscle.
RESULTS AND CONCLUSION:Insulin-like growth factor, fibroblast growth factor and hepatocyte growth factor regulate inflammation after skeletal muscle injury extensively. Myosin heavy chain is considered as a specific marker for skeletal muscle regeneration. Types I and III col agen and fibronectin functioning as a skeleton for skeletal muscle fiber play critical roles in the regeneration and repair of injured skeletal muscle.
