Effects of Rehabilitation Surgery Assisted to FOLFOX Chemotherapy on Postoperative Recovery,Complica-tions and Quality of Life in Patients with Colorectal Cancer
10.6039/j.issn.1001-0408.2016.27.10
- VernacularTitle:快速康复外科辅助FOLFOX化疗方案对结直肠癌患者术后恢复、并发症及生存质量的影响Δ
- Author:
Rong LU
;
Junlei LI
;
Ping JIA
;
Rong CHEN
- Publication Type:Journal Article
- Keywords:
Rapid rehabilitation surgery;
Fluorouracil;
Oxaliplatin;
Leucovorin;
Colorectal cancer;
Quality of life;
Complica-tion;
Postoperative recovery
- From:
China Pharmacy
2016;27(27):3774-3776
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of rapid rehabilitation surgery assisted to fluorouracil,oxaliplatin,leucovo-rin(FOLFOX)on postoperative recovery,complications and quality of life in patients with colorectal cancer. METHODS:60 pa-tients with colorectal cancer were randomly divided into control group(30 cases)and observation group(30 cases). After resection of colorectal cancer,control group received 85 mg/m2 Oxaliplatin for injection,2 h intravenous infusion,d1+200 mg/m2 Calcium le-vofolinate for injection,intravenous infusion,once a day,d1-2+400 mg/m2 Fluorouracil injection,intravenous infusion,once a day, d1-5 then 600 mg/m2 for 22 h intravenous infusion,d1-2. Observation was additionally given rapid rehabilitation surgery. 2-week was regarded as 1 course,it lasted 12 courses. Urinary retention time,anal exhaust time,first defecation time,postoperative hospital-ization time,scores of life quality (overall health,emotional function,mental health,physiological functions,physical function,so-matic pain,vitality,social function)in 2 groups were observed,and the incidence of postoperative complications was recorded. RE-SULTS:The urinary retention time,anal exhaust time,first defecation time,postoperative hospitalization time in observation group were significantly shorter than control group,the incidence of postoperative complications in observation group was signifi-cantly lower than control group,overall health,emotional function and mental health score were significantly higher than control group,the differences were statistically significant(P<0.05),but there were no significant differences in physiological functions, physical function,somatic pain,vitality,social function score in 2 groups (P>0.05). CONCLUSIONS:Rapid rehabilitation sur-gery assisted to FOLFOX chemotherapy can reduce the incidence of postoperative complications in patients with colorectal cancer, improve quality of life,shorten hospitalization time and promote postoperative recovery.
