Twist regulation of EMT and its clinical significance in monitoring circulating tumor cells and evaluating effects of anticancer drugs
10.3969/j.issn.1000-8179.2016.17.464
- VernacularTitle:Twist对EMT调控在循环肿瘤细胞监测与抗癌药物评价中的临床意义
- Author:
Wenqing LI
;
Yi DING
;
Yu JIANG
;
Zhong LU
;
Lihua WANG
- Publication Type:Journal Article
- Keywords:
Twist;
epithelial-mesenchymal transition;
circulating tumor cells;
tumor biomarkers;
anticancer drugs
- From:
Chinese Journal of Clinical Oncology
2016;43(17):770-774
- CountryChina
- Language:Chinese
-
Abstract:
Tumor cell plasticity, including epithelial to mesenchymal transition (EMT) and its reverse program, mesenchymal to epithe-lial transition (MET), regulates circulating tumor cells and carcinoma metastasis. Twist is overexpressed in rhabdomyosarcoma, breast cancer, gastric cancer, and other tumors. Twist, as a transcriptional factor, cross-talks with multiple signaling pathways, forming a com-plex network to participate in the regulation of EMT/MET in circulating tumor cells, which in turn promotes metastasis of tumor cells. Therefore, monitoring the level of Twist and epithelial–mesenchymal phenotypic molecules is important as it may be beneficial for in-creasing the detection ratio of circulating tumor cells as tumor biomarkers and for evaluating the effects of anticancer drugs.
